Current Openings

Tarveda Therapeutics, Inc. is a clinical stage biotechnology company that discovers and develops Pentarins™, a new class of potent and selective miniaturized drug conjugates with enhanced targeting capabilities for the treatment of solid cancer tumors. Tarveda’s lead Pentarin drug candidate, PEN-221, is a miniaturized drug conjugate that targets the somatostatin receptor 2 (SSTR2) for treatment of patients with neuroendocrine and small cell lung cancers. PEN-221 comprises a highly selective peptide that targets SSTR2 linked to the potent cytotoxic DM1 through a cleavable linker.

Tarveda is also advancing its HSP90 drug conjugate platform with lead drug candidate PEN-866, which is a miniaturized HSP90 targeting drug conjugate that comprises a small molecule HSP90 targeting ligand conjugated to SN-38, the highly potent, active metabolite of irinotecan. Tarveda’s strategy includes developing its own proprietary Pentarins as well as applying the Pentarin platform to enhance the effectiveness of the targeting moieties and novel payloads of pharmaceutical collaborators.

Position Summary:

We are seeking an exceptional individual to hire as Scientist I in our Formulation and Analytical Chemistry group. The successful candidate will work both independently and with the group to evaluate early discovery compounds and develop formulations for preclinical and early human studies for our experimental compounds to address the specific challenges associated with drug solubility, bioavailability, and/or physical/chemical stability.

Essential Functions:

  • Develop and characterize parenteral formulations for small molecules and peptide conjugates to support non-clinical and early clinical drug development carried in-house and at CROs
  • Design and execute experiments to support novel formulations stability and characterization for in vivo testing
  • Collaborate with chemistry, process development, and biology teams to define desired formulation attributes
  • Develop analytical methods to assess drug purity, formulation stability and potency
  • Perform routine HPLC analysis for formulation stability and dose verification
  • Support Chemistry team by carrying out stability studies for new chemical entities, starting and reference materials
  • Keep abreast of research literature and apply new relevant concepts to solve challenges related to drug solubility, aggregation and chemical stability
  • Develop new and refine existing formulations of drug product for leading candidates
  • Prepare and execute study protocols, technical reports and materials specifications and maintain appropriate records
  • Actively participate in cross-functional project teams as a representative of the Formulation group

Education and Experience:

  • MS with 5+ years of experience or equivalent in Pharmaceutical Sciences, Formulation Development, and/or Analytical Development for novel oncology products
  • Hands on experience in early stages of formulation development, and characterization of parenteral products
  • Experience with key analytical methods: HPLC, Karl Fisher, and DLS
  • Expertise in formulation developments of BCS class III and IV as well as knowledge of cytotoxic materials handling and operations is a plus

Required Competencies:

  • Team oriented
  • Effective communicator (written and verbal)
  • Detail oriented
  • Independent
  • Results oriented
  • Multitasker
  • Strong sense of urgency

Tarveda Therapeutics is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

Please send your resume and a brief cover letter describing why you should be considered for the position to the

Tarveda Therapeutics, Inc., 134 Coolidge Ave., Watertown, MA 02472